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Differential susceptibility to plasticity: a 'missing link' between gene-culture co-evolution and neuropsychiatric spectrum disorders?

Overview of attention for article published in BMC Medicine, April 2012
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Title
Differential susceptibility to plasticity: a 'missing link' between gene-culture co-evolution and neuropsychiatric spectrum disorders?
Published in
BMC Medicine, April 2012
DOI 10.1186/1741-7015-10-37
Pubmed ID
Authors

Rachel Wurzman, James Giordano

Abstract

Brüne's proposal that erstwhile 'vulnerability' genes need to be reconsidered as 'plasticity' genes, given the potential for certain environments to yield increased positive function in the same domain as potential dysfunction, has implications for psychiatric nosology as well as a more dynamic understanding of the relationship between genes and culture. In addition to validating neuropsychiatric spectrum disorder nosologies by calling for similar methodological shifts in gene-environment-interaction studies, Brüne's position elevates the importance of environmental contexts - inclusive of socio-cultural variables - as mechanisms that contribute to clinical presentation. We assert that when models of susceptibility to plasticity and neuropsychiatric spectrum disorders are concomitantly considered, a new line of inquiry emerges into the co-evolution and co-determination of socio-cultural contexts and endophenotypes. This presents potentially unique opportunities, benefits, challenges, and responsibilities for research and practice in psychiatry. Please see related manuscript: http://www.biomedcentral.com/1741-7015/10/38.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 25%
Student > Ph. D. Student 8 22%
Professor 5 14%
Other 4 11%
Student > Master 3 8%
Other 7 19%
Readers by discipline Count As %
Psychology 12 33%
Medicine and Dentistry 6 17%
Agricultural and Biological Sciences 6 17%
Neuroscience 5 14%
Social Sciences 3 8%
Other 2 6%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2012.
All research outputs
#23,010,126
of 25,654,806 outputs
Outputs from BMC Medicine
#3,888
of 4,067 outputs
Outputs of similar age
#159,491
of 175,324 outputs
Outputs of similar age from BMC Medicine
#31
of 31 outputs
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