You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
An update on targeted gene repair in mammalian cells: methods and mechanisms
|
|---|---|
| Published in |
Journal of Biomedical Science, February 2011
|
| DOI | 10.1186/1423-0127-18-10 |
| Pubmed ID | |
| Authors |
Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund, Thomas G Jensen |
| Abstract |
Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) has recently become a promising alternative to this method. By means of TGA, endogenous DNA repair pathways of the cell are activated leading to specific genetic correction of single-base mutations in the genome. This strategy can be implemented using single-stranded oligodeoxyribonucleotides (ssODNs), small DNA fragments (SDFs), triplex-forming oligonucleotides (TFOs), adeno-associated virus vectors (AAVs) and zinc-finger nucleases (ZFNs). Despite difficulties in the use of TGA, including lack of knowledge on the repair mechanisms stimulated by the individual methods, the field holds great promise for the future. The objective of this review is to summarize and evaluate the different methods that exist within this particular area of human gene therapy research. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | 2% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Ireland | 1 | <1% |
| South Africa | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 126 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 24% |
| Researcher | 32 | 24% |
| Student > Master | 16 | 12% |
| Other | 9 | 7% |
| Student > Doctoral Student | 7 | 5% |
| Other | 23 | 17% |
| Unknown | 16 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 70 | 51% |
| Biochemistry, Genetics and Molecular Biology | 29 | 21% |
| Medicine and Dentistry | 11 | 8% |
| Physics and Astronomy | 2 | 1% |
| Immunology and Microbiology | 2 | 1% |
| Other | 6 | 4% |
| Unknown | 16 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2021.
All research outputs
#7,355,485
of 25,371,288 outputs
Outputs from Journal of Biomedical Science
#304
of 1,100 outputs
Outputs of similar age
#50,605
of 193,364 outputs
Outputs of similar age from Journal of Biomedical Science
#3
of 9 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,100 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,364 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.