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Zinc Finger Nucleases as tools to understand and treat human diseases

Overview of attention for article published in BMC Medicine, July 2010
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Mentioned by

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1 tweeter

Citations

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36 Dimensions

Readers on

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127 Mendeley
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2 CiteULike
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Title
Zinc Finger Nucleases as tools to understand and treat human diseases
Published in
BMC Medicine, July 2010
DOI 10.1186/1741-7015-8-42
Pubmed ID
Authors

David Davis, David Stokoe

Abstract

Recent work has shown that it is possible to target regulatory elements to DNA sequences of an investigator's choosing, increasing the armamentarium for probing gene function. In this review, we discuss the development and use of designer zinc finger proteins (ZFPs) as sequence specific tools. While the main focus of this review is to discuss the attachment of the FokI nuclease to ZFPs and the ability of the resulting fusion protein (termed zinc finger nucleases (ZFNs)) to genomically manipulate a gene of interest, we will also cover the utility of other functional domains, such as transcriptional activators and repressors, and highlight how these are being used as discovery and therapeutic tools.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 4%
Spain 2 2%
India 1 <1%
South Africa 1 <1%
Belarus 1 <1%
Mexico 1 <1%
France 1 <1%
Germany 1 <1%
Unknown 114 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 29%
Student > Ph. D. Student 35 28%
Student > Master 14 11%
Student > Bachelor 10 8%
Student > Doctoral Student 6 5%
Other 18 14%
Unknown 7 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 58%
Biochemistry, Genetics and Molecular Biology 21 17%
Medicine and Dentistry 16 13%
Chemistry 6 5%
Physics and Astronomy 1 <1%
Other 2 2%
Unknown 7 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2012.
All research outputs
#12,357,379
of 18,796,528 outputs
Outputs from BMC Medicine
#2,548
of 2,817 outputs
Outputs of similar age
#83,355
of 136,331 outputs
Outputs of similar age from BMC Medicine
#1
of 1 outputs
Altmetric has tracked 18,796,528 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,817 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,331 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them