↓ Skip to main content

Characterization of C-strain “Riems” TAV-epitope escape variants obtained through selective antibody pressure in cell culture

Overview of attention for article published in Veterinary Research, April 2012
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
16 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Characterization of C-strain “Riems” TAV-epitope escape variants obtained through selective antibody pressure in cell culture
Published in
Veterinary Research, April 2012
DOI 10.1186/1297-9716-43-33
Pubmed ID
Authors

Immanuel Leifer, Sandra Blome, Ulrike Blohm, Patricia König, Heike Küster, Bodo Lange, Martin Beer

Abstract

Classical swine fever virus (CSFV) C-strain "Riems" escape variants generated under selective antibody pressure with monoclonal antibodies and a peptide-specific antiserum in cell culture were investigated. Candidates with up to three amino acid exchanges in the immunodominant and highly conserved linear TAV-epitope of the E2-glycoprotein, and additional mutations in the envelope proteins ERNS and E1, were characterized both in vitro and in vivo.It was further demonstrated, that intramuscular immunization of weaner pigs with variants selected after a series of passages elicited full protection against lethal CSFV challenge infection. These novel CSFV C-strain variants with exchanges in the TAV-epitope present potential marker vaccine candidates. The DIVA (differentiating infected from vaccinated animals) principle was tested for those variants using commercially available E2 antibody detection ELISA. Moreover, direct virus differentiation is possible using a real-time RT-PCR system specific for the new C-strain virus escape variants or using differential immunofluorescence staining.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 38%
Researcher 5 31%
Student > Master 2 13%
Student > Bachelor 1 6%
Professor > Associate Professor 1 6%
Other 0 0%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 44%
Biochemistry, Genetics and Molecular Biology 4 25%
Veterinary Science and Veterinary Medicine 2 13%
Immunology and Microbiology 1 6%
Engineering 1 6%
Other 0 0%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2012.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Veterinary Research
#1,199
of 1,337 outputs
Outputs of similar age
#158,140
of 173,920 outputs
Outputs of similar age from Veterinary Research
#14
of 16 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,920 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.