Title |
Cyclin K goes with Cdk12 and Cdk13
|
---|---|
Published in |
Cell Division, April 2012
|
DOI | 10.1186/1747-1028-7-12 |
Pubmed ID | |
Authors |
Jiri Kohoutek, Dalibor Blazek |
Abstract |
The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. |
X Demographics
Geographical breakdown
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
France | 1 | 1% |
Canada | 1 | 1% |
Finland | 1 | 1% |
Japan | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 93 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 16% |
Researcher | 16 | 16% |
Student > Master | 15 | 15% |
Student > Bachelor | 6 | 6% |
Professor | 4 | 4% |
Other | 14 | 14% |
Unknown | 29 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 28% |
Agricultural and Biological Sciences | 25 | 25% |
Medicine and Dentistry | 6 | 6% |
Chemistry | 5 | 5% |
Immunology and Microbiology | 4 | 4% |
Other | 4 | 4% |
Unknown | 28 | 28% |