Title |
Clinical applications of fundus autofluorescence in retinal disease
|
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Published in |
International Journal of Retina and Vitreous , April 2016
|
DOI | 10.1186/s40942-016-0035-x |
Pubmed ID | |
Authors |
Madeline Yung, Michael A. Klufas, David Sarraf |
Abstract |
Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Multiple commercially available imaging systems, including the fundus camera, the confocal scanning laser ophthalmoscope, and the ultra-widefield imaging device, are available to the clinician. Each offers unique advantages for evaluating various retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating age related macular degeneration, macular dystrophies, retinitis pigmentosa, white dot syndromes, retinal drug toxicities, and various other retinal disorders. FAF may detect abnormalities beyond those detected on funduscopic exam, fluorescein angiography, or optical coherence tomography, and can be used to elucidate disease pathogenesis, form genotype-phenotype correlations, diagnose and monitor disease, and evaluate novel therapies. Given its ease of use, non-invasive nature, and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes common ocular fluorophores, imaging modalities, and FAF findings for a wide spectrum of retinal disorders. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 246 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 30 | 12% |
Researcher | 29 | 12% |
Student > Ph. D. Student | 26 | 11% |
Student > Master | 24 | 10% |
Student > Postgraduate | 22 | 9% |
Other | 50 | 20% |
Unknown | 66 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 79 | 32% |
Engineering | 20 | 8% |
Biochemistry, Genetics and Molecular Biology | 17 | 7% |
Nursing and Health Professions | 13 | 5% |
Physics and Astronomy | 11 | 4% |
Other | 36 | 15% |
Unknown | 71 | 29% |