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Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance

Overview of attention for article published in Nutrition & Metabolism, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
16 X users
patent
2 patents
facebook
1 Facebook page
video
1 YouTube creator

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
64 Mendeley
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Title
Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance
Published in
Nutrition & Metabolism, April 2016
DOI 10.1186/s12986-016-0088-8
Pubmed ID
Authors

Manuel Manzano, María D Giron, José D. Vilchez, Natalia Sevillano, Nuri El-Azem, Ricardo Rueda, Rafael Salto, Jose M. Lopez-Pedrosa

Abstract

Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an apple polyphenol extract (APE) in an insulin-resistant rat model and to determine the molecular basis of insulin sensitivity action in skeletal muscle cells. Acute effect of APE on the postprandial hyperglycemic response was assayed in 15 week old obese Zucker rats (OZR), by using a meal tolerance test (MTT). The ability of APE to improve whole peripheral insulin sensitivity was also assayed in a chronic study by using the euglycemic-hyperinsulinemic clamp technique. To elucidate the molecular mechanisms, rat L6 myotubes were used. Glucose uptake was measured by using 2-[3H]-Deoxy-Glucose (2-DG) and specific inhibitors, as well as phosphorylation status of key kinases, were used to determine the implicated signaling pathway. In vivo study showed that nutritional intervention with APE induced an increase of insulin sensitivity with an increase of glucose infusion rate (GIR) of 45 %. Additionally, in vitro results showed a synergistic effect between APE and insulin as well as increased glucose uptake through GLUT4 translocation in muscle cells. This translocation was mediated by phosphatydil inositol 3-kinase (PI3K) and peroxisome proliferator-activated receptor-gamma (PPARγ) signaling pathways. As a whole, this study describes the mechanisms involved in the insulin sensitizing effect of APE, which could be considered a promising ingredient for inclusion in nutritional products focused on the management of chronic diseases such as diabetes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 16%
Student > Ph. D. Student 8 13%
Researcher 7 11%
Student > Doctoral Student 5 8%
Student > Postgraduate 5 8%
Other 14 22%
Unknown 15 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 19%
Agricultural and Biological Sciences 11 17%
Medicine and Dentistry 6 9%
Nursing and Health Professions 5 8%
Chemistry 4 6%
Other 9 14%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 46. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2023.
All research outputs
#908,164
of 25,542,788 outputs
Outputs from Nutrition & Metabolism
#145
of 1,020 outputs
Outputs of similar age
#15,740
of 312,503 outputs
Outputs of similar age from Nutrition & Metabolism
#3
of 16 outputs
Altmetric has tracked 25,542,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,020 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,503 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.