↓ Skip to main content

Trafficking in and to the primary cilium

Overview of attention for article published in Cilia, April 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
3 blogs
policy
1 policy source

Citations

dimensions_citation
105 Dimensions

Readers on

mendeley
324 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Trafficking in and to the primary cilium
Published in
Cilia, April 2012
DOI 10.1186/2046-2530-1-4
Pubmed ID
Authors

Yi-Chun Hsiao, Karina Tuz, Russell J Ferland

Abstract

Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the primary cilium. The primary cilium, which is found on almost every cell type in vertebrates, is an organelle that protrudes from the surface of the cell and functions as a signaling center. Interestingly, it has recently been linked to a variety of human diseases, collectively referred to as ciliopathies. The primary cilium has an exceptionally high density of receptors on its membrane that are important for sensing and transducing extracellular stimuli. Moreover, the primary cilium serves as a separate cellular compartment from the cytosol, providing for unique spatial and temporal regulation of signaling molecules to initiate downstream events. Thus, functional primary cilia are essential for normal signal transduction. Rabs and Arls/Arfs play critical roles in early cilia formation but are also needed for maintenance of ciliary function through their coordination with intraflagellar transport (IFT), a specialized trafficking system in primary cilia. IFT in cilia is pivotal for the proper movement of proteins into and out of this highly regulated organelle. In this review article, we explore the involvement of polarized vesicular trafficking in cilia formation and function, and discuss how defects in these processes could subsequently lead to the abnormalities observed in ciliopathies.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 324 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
France 2 <1%
Korea, Republic of 2 <1%
United Kingdom 1 <1%
Netherlands 1 <1%
Israel 1 <1%
Canada 1 <1%
Unknown 313 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 84 26%
Researcher 65 20%
Student > Master 43 13%
Student > Bachelor 40 12%
Student > Doctoral Student 19 6%
Other 35 11%
Unknown 38 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 137 42%
Biochemistry, Genetics and Molecular Biology 91 28%
Neuroscience 14 4%
Medicine and Dentistry 13 4%
Engineering 8 2%
Other 20 6%
Unknown 41 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2022.
All research outputs
#1,714,286
of 23,839,820 outputs
Outputs from Cilia
#6
of 91 outputs
Outputs of similar age
#10,272
of 165,545 outputs
Outputs of similar age from Cilia
#2
of 7 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 91 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,545 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.