Title |
Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions
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Published in |
BMC Musculoskeletal Disorders, January 2011
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DOI | 10.1186/1471-2474-12-27 |
Pubmed ID | |
Authors |
Deborah L Reichart, Richard T Hinkle, Frank R Lefever, Elizabeth T Dolan, Jeffrey A Dietrich, David R Sibley, Robert J Isfort |
Abstract |
Control of skeletal muscle mass and force production is a complex physiological process involving numerous regulatory systems. Agents that increase skeletal muscle cAMP levels have been shown to modulate skeletal muscle mass and force production. The dopamine 1 receptor and its closely related homolog, the dopamine 5 receptor, are G-protein coupled receptors that are expressed in skeletal muscle and increase cAMP levels when activated. Thus we hypothesize that activation of the dopamine 1 and/or 5 receptor will increase skeletal muscle cAMP levels thereby modulating skeletal muscle mass and force production. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Canada | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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New Zealand | 1 | 4% |
United States | 1 | 4% |
Unknown | 25 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 26% |
Researcher | 3 | 11% |
Student > Master | 3 | 11% |
Student > Bachelor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 3 | 11% |
Unknown | 7 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 15% |
Sports and Recreations | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 11% |
Nursing and Health Professions | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Other | 5 | 19% |
Unknown | 7 | 26% |