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Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma

Overview of attention for article published in BMC Genomics, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

patent
2 patents

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma
Published in
BMC Genomics, May 2012
DOI 10.1186/1471-2164-13-160
Pubmed ID
Authors

Elana J Fertig, Qing Ren, Haixia Cheng, Hiromitsu Hatakeyama, Adam P Dicker, Ulrich Rodeck, Michael Considine, Michael F Ochs, Christine H Chung

Abstract

Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the mechanisms of cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous cell carcinoma (HNSCC). To infer relevant and specific pathway activation downstream of EGFR from gene expression in HNSCC, we generated gene expression signatures using immortalized keratinocytes (HaCaT) subjected to ligand stimulation and transfected with EGFR, RELA/p65, or HRASVal12D.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 5%
United States 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 31%
Student > Master 7 17%
Student > Ph. D. Student 5 12%
Other 3 7%
Professor 3 7%
Other 8 19%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 40%
Medicine and Dentistry 8 19%
Computer Science 5 12%
Biochemistry, Genetics and Molecular Biology 4 10%
Mathematics 2 5%
Other 3 7%
Unknown 3 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2022.
All research outputs
#5,446,210
of 25,371,288 outputs
Outputs from BMC Genomics
#2,155
of 11,244 outputs
Outputs of similar age
#35,493
of 175,822 outputs
Outputs of similar age from BMC Genomics
#19
of 113 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,822 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.