Title |
Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks
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Published in |
BMC Systems Biology, May 2012
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DOI | 10.1186/1752-0509-6-29 |
Pubmed ID | |
Authors |
Daniel C Kirouac, Julio Saez-Rodriguez, Jennifer Swantek, John M Burke, Douglas A Lauffenburger, Peter K Sorger |
Abstract |
Understanding the information-processing capabilities of signal transduction networks, how those networks are disrupted in disease, and rationally designing therapies to manipulate diseased states require systematic and accurate reconstruction of network topology. Data on networks central to human physiology, such as the inflammatory signalling networks analyzed here, are found in a multiplicity of on-line resources of pathway and interactome databases (Cancer CellMap, GeneGo, KEGG, NCI-Pathway Interactome Database (NCI-PID), PANTHER, Reactome, I2D, and STRING). We sought to determine whether these databases contain overlapping information and whether they can be used to construct high reliability prior knowledge networks for subsequent modeling of experimental data. |
X Demographics
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Country | Count | As % |
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United States | 1 | 20% |
Guinea | 1 | 20% |
Germany | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 9 | 4% |
Germany | 3 | 1% |
France | 2 | <1% |
Spain | 2 | <1% |
Italy | 2 | <1% |
Netherlands | 1 | <1% |
Latvia | 1 | <1% |
United Kingdom | 1 | <1% |
Turkey | 1 | <1% |
Other | 4 | 2% |
Unknown | 199 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 65 | 29% |
Researcher | 60 | 27% |
Professor > Associate Professor | 15 | 7% |
Student > Master | 15 | 7% |
Other | 12 | 5% |
Other | 45 | 20% |
Unknown | 13 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 106 | 47% |
Biochemistry, Genetics and Molecular Biology | 37 | 16% |
Computer Science | 18 | 8% |
Engineering | 13 | 6% |
Medicine and Dentistry | 11 | 5% |
Other | 19 | 8% |
Unknown | 21 | 9% |