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BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

Overview of attention for article published in BMC Biology, April 2012
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Title
BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway
Published in
BMC Biology, April 2012
DOI 10.1186/1741-7007-10-37
Pubmed ID
Authors

Jessica Kopf, Ansgar Petersen, Georg N Duda, Petra Knaus

Abstract

Efficient osteogenic differentiation is highly dependent on coordinated signals arising from growth factor signalling and mechanical forces. Bone morphogenetic proteins (BMPs) are secreted proteins that trigger Smad and non-Smad pathways and thereby influence transcriptional and non-transcriptional differentiation cues. Crosstalk at multiple levels allows for promotion or attenuation of signalling intensity and specificity. Similar to BMPs, mechanical stimulation enhances bone formation. However, the molecular mechanism by which mechanical forces crosstalk to biochemical signals is still unclear.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 2%
United Kingdom 1 <1%
United States 1 <1%
Germany 1 <1%
Unknown 107 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 25%
Researcher 25 22%
Student > Master 18 16%
Student > Bachelor 8 7%
Student > Doctoral Student 6 5%
Other 16 14%
Unknown 11 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 27%
Engineering 18 16%
Biochemistry, Genetics and Molecular Biology 17 15%
Medicine and Dentistry 15 13%
Physics and Astronomy 6 5%
Other 12 11%
Unknown 14 13%