Title |
Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study
|
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Published in |
Malaria Journal, April 2012
|
DOI | 10.1186/1475-2875-11-140 |
Pubmed ID | |
Authors |
Rashid A Khatib, Jacek Skarbinski, Joseph D Njau, Catherine A Goodman, Berty F Elling, Elizeus Kahigwa, Jacquelin M Roberts, John R MacArthur, Julie R Gutman, Abdunoor M Kabanywanyi, Ernest E Smith, Masha F Somi, Thomas Lyimo, Alex Mwita, Blaise Genton, Marcel Tanner, Anne Mills, Hassan Mshinda, Peter B Bloland, Salim M Abdulla, S Patrick Kachur |
Abstract |
Artemisinin-based combination therapy (ACT) has been promoted as a means to reduce malaria transmission due to their ability to kill both asexual blood stages of malaria parasites, which sustain infections over long periods and the immature derived sexual stages responsible for infecting mosquitoes and onward transmission. Early studies reported a temporal association between ACT introduction and reduced malaria transmission in a number of ecological settings. However, these reports have come from areas with low to moderate malaria transmission, been confounded by the presence of other interventions or environmental changes that may have reduced malaria transmission, and have not included a comparison group without ACT. This report presents results from the first large-scale observational study to assess the impact of case management with ACT on population-level measures of malaria endemicity in an area with intense transmission where the benefits of effective infection clearance might be compromised by frequent and repeated re-infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Tanzania, United Republic of | 4 | 4% |
United States | 2 | 2% |
Australia | 1 | 1% |
Indonesia | 1 | 1% |
Belgium | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 90 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 20% |
Student > Ph. D. Student | 14 | 14% |
Student > Master | 13 | 13% |
Student > Bachelor | 7 | 7% |
Professor > Associate Professor | 5 | 5% |
Other | 22 | 22% |
Unknown | 19 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 37% |
Social Sciences | 10 | 10% |
Agricultural and Biological Sciences | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Nursing and Health Professions | 3 | 3% |
Other | 17 | 17% |
Unknown | 20 | 20% |