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Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPreslevel disparity

Overview of attention for article published in Molecular Neurodegeneration, April 2012
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Title
Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPreslevel disparity
Published in
Molecular Neurodegeneration, April 2012
DOI 10.1186/1750-1326-7-18
Pubmed ID
Authors

Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins

Abstract

Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrPres) conformers of the normal cellular prion protein (PrPC), with the former posited to be the principal constituent of the infectious 'prion'. Unexplained discrepancies observed between detectable PrPres and infectivity levels exemplify the complexity in deciphering the exact biophysical nature of prions and those host cell factors, if any, which contribute to transmission efficiency. In order to improve our understanding of these important issues, this study utilized a bioassay validated cell culture model of prion infection to investigate discordance between PrPres levels and infectivity titres at a subcellular resolution.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Researcher 7 27%
Professor 4 15%
Student > Master 2 8%
Other 1 4%
Other 1 4%
Unknown 3 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 31%
Agricultural and Biological Sciences 7 27%
Neuroscience 3 12%
Immunology and Microbiology 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Other 1 4%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2012.
All research outputs
#18,305,773
of 22,664,644 outputs
Outputs from Molecular Neurodegeneration
#780
of 842 outputs
Outputs of similar age
#126,170
of 163,378 outputs
Outputs of similar age from Molecular Neurodegeneration
#9
of 11 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.