Title |
Complete genome sequence of an agr-dysfunctional variant of the ST239 lineage of the methicillin-resistant Staphylococcus aureus strain GV69 from Brazil
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Published in |
Environmental Microbiome, May 2016
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DOI | 10.1186/s40793-016-0154-x |
Pubmed ID | |
Authors |
Ana M. N. Botelho, Maiana O. C. Costa, Cristiana O. Beltrame, Fabienne A. Ferreira, Marina F. Côrtes, Paula T. Bandeira, Nicholas C. B. Lima, Rangel C. Souza, Luiz G. P. Almeida, Ana T. R. Vasconcelos, Marisa F. Nicolás, Agnes M. S. Figueiredo |
Abstract |
Staphylococcus aureus is a versatile Gram-positive coccus frequently found colonizing the skin and nasal membranes of humans. The acquisition of the staphylococcal cassette chromosome mec was a major milestone in the evolutionary path of methicillin-resistant S. aureus. This genetic element carries the mecA gene, the main determinant of methicillin resistance. MRSA is involved in a plethora of opportunistic infectious diseases. The accessory gene regulator is the major S. aureus quorum sensing system, playing an important role in staphylococcal virulence, including the development of biofilms. We report the complete genome sequence (NCBI BioProject ID: PRJNA264181) of the methicillin-resistant S. aureus strain GV69 (= CMVRS P4521), a variant of the ST239 lineage that presents with a natural attenuation of agr-RNAIII transcription and a moderate accumulation of biofilm. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 21% |
Researcher | 7 | 18% |
Student > Ph. D. Student | 4 | 11% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Other | 6 | 16% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 21% |
Immunology and Microbiology | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Nursing and Health Professions | 3 | 8% |
Other | 6 | 16% |
Unknown | 6 | 16% |