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Radiotherapy for gynecologic cancer in nonagenarian patients: a framework for new paradigms

Overview of attention for article published in Cancer Communications, May 2016
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Title
Radiotherapy for gynecologic cancer in nonagenarian patients: a framework for new paradigms
Published in
Cancer Communications, May 2016
DOI 10.1186/s40880-016-0104-4
Pubmed ID
Authors

Benoîte Méry, Sylvie Mengue Ndong, Jean-Baptiste Guy, Avi Assouline, Alexander T. Falk, Anaïs Valeille, Jane-Chloé Trone, Romain Rivoirard, Pierre Auberdiac, Alexis Vallard, Sophie Espenel, Guillaume Moriceau, Olivier Collard, Claire Bosacki, Jean-Philippe Jacquin, Guy de Laroche, Pierre Fournel, Cyrus Chargari, Nicolas Magné

Abstract

No consensus exists regarding the role of radiotherapy in the management of gynecologic cancer in nonagenarian patients. We retrospectively reviewed the outcomes of 19 consecutive nonagenarian patients with gynecologic cancer (6 endometrial cancers, 6 cervical cancers, 4 vulvar cancers, and 3 vaginal cancers) who were treated with radiotherapy. Radiotherapy was performed mainly in a palliative setting (n = 12; 63.2%), with a median dose of 45 Gy (range, 6-76 Gy). Infrequent major acute or late toxicities were reported. Among 19 patients, 9 (47.4%) experienced tumor progression, 5 (26.3%) experienced complete response, 2 (10.5%) experienced stable disease and/or partial response. At last follow-up, 12 patients (63.2%) had died; most deaths (n = 9) occurred because of the cancer. These results suggest that radiotherapy is feasible in the treatment of nonagenarian patients with gynecologic cancer.

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 18%
Researcher 3 18%
Student > Bachelor 2 12%
Student > Postgraduate 2 12%
Student > Master 2 12%
Other 1 6%
Unknown 4 24%
Readers by discipline Count As %
Medicine and Dentistry 7 41%
Nursing and Health Professions 3 18%
Economics, Econometrics and Finance 1 6%
Agricultural and Biological Sciences 1 6%
Unknown 5 29%