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Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

Overview of attention for article published in Arthritis Research & Therapy, May 2012
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Title
Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis
Published in
Arthritis Research & Therapy, May 2012
DOI 10.1186/ar3832
Pubmed ID
Authors

Masaru Kimata, David L Cullins, Monica L Brown, David D Brand, Edward F Rosloniec, Linda K Myers, John M Stuart, Andrew H Kang

Abstract

We used DR1 transgenic mice and covalently linked DR1 multimers to characterize analog-specific inhibitory T cells in collagen-induced arthritis (CIA). Because of the low numbers of antigen-specific T cells in wild-type mice, functional T-cell studies in autoimmune arthritis have been challenging. The use of T-cell receptor (TCR) transgenic mice has provided useful information, but such T cells may not represent the heterogeneous T-cell response that occurs in natural settings. Our focus was to develop tools to identify and characterize the population of immunoregulatory T cells induced in wild-type mice by an analog peptide of CII259-273, which contains amino acid substitutions at positions 263 (N) and 266 (D) (analog peptide A12).

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 32%
Student > Master 4 21%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Other 1 5%
Other 3 16%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 7 37%
Agricultural and Biological Sciences 3 16%
Biochemistry, Genetics and Molecular Biology 2 11%
Immunology and Microbiology 1 5%
Environmental Science 1 5%
Other 2 11%
Unknown 3 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2012.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,380 outputs
Outputs of similar age
#115,461
of 176,040 outputs
Outputs of similar age from Arthritis Research & Therapy
#49
of 73 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.