We later showed that this can actually be leveraged to select better guides: if multiple tools agree on a given sgRNA, then it is more likely to be good. It can be used to build consensus approaches: https://t.co/tXJb1WCpkG However, they can be computation
Existing tools often do not agree with each other, but we previously showed that, when they do, the corresponding gRNAs are better (https://t.co/LFbDlmUGHV). Here, we take advantage of this and combine three different approaches to select guides. (2/4)
RT @jakebradfordqut: Just in time for the end of the decade: @dperrin and I present our latest paper on improving #CRISPR-Cas9 guide design…
RT @ScienceCrisp: Improving #CRISPR guide design with consensus approaches. Bradford J, Perrin D. BMC Genomics. 2019-12-24 https://t.co/nN…