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Impact of maternally derived immunity on piglets’ immune response and protection against porcine circovirus type 2 (PCV2) after vaccination against PCV2 at different age

Overview of attention for article published in BMC Veterinary Research, May 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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1 tweeter
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1 patent

Citations

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15 Dimensions

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60 Mendeley
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Title
Impact of maternally derived immunity on piglets’ immune response and protection against porcine circovirus type 2 (PCV2) after vaccination against PCV2 at different age
Published in
BMC Veterinary Research, May 2016
DOI 10.1186/s12917-016-0700-1
Pubmed ID
Authors

Paolo Martelli, Roberta Saleri, Giulia Ferrarini, Elena De Angelis, Valeria Cavalli, Michele Benetti, Luca Ferrari, Elena Canelli, Paolo Bonilauri, Elena Arioli, Antonio Caleffi, Heiko Nathues, Paolo Borghetti

Abstract

This study was aimed at evaluating the clinical protection, the level of Porcine circovirus type 2 (PCV2) viremia and the immune response (antibodies and IFN-γ secreting cells (SC)) in piglets derived from PCV2 vaccinated sows and themselves vaccinated against PCV2 at different age, namely at 4, 6 and 8 weeks. The cohort study has been carried out over three subsequent production cycles (replicates). At the start/enrolment, 46 gilts were considered at first mating, bled and vaccinated. At the first, second and third farrowing, dams were bled and re-vaccinated at the subsequent mating after weaning piglets. Overall 400 piglets at each farrowing (first, second and third) were randomly allocated in three different groups (100 piglets/group) based on the timing of vaccination (4, 6 or 8 weeks of age). A fourth group was kept non-vaccinated (controls). Piglets were vaccinated intramuscularly with one dose (2 mL) of a commercial PCV2a-based subunit vaccine (Porcilis® PCV). Twenty animals per group were bled at weaning and from vaccination to slaughter every 4 weeks for the detection of PCV2 viremia, humoral and cell-mediated immune responses. Clinical signs and individual treatments (morbidity), mortality, and body weight of all piglets were recorded. All vaccination schemes (4, 6 and 8 weeks of age) were able to induce an antibody response and IFN-γ SC. The highest clinical and virological protection sustained by immune reactivity was observed in pigs vaccinated at 6 weeks of age. Overall, repeated PCV2 vaccination in sows at mating and the subsequent higher levels of maternally derived antibodies did not significantly interfere with the induction of both humoral and cell-mediated immunity in their piglets after vaccination. The combination of vaccination in sows at mating and in piglets at 6 weeks of age was more effective for controlling PCV2 natural infection, than other vaccination schemas, thus sustaining that some interference of MDA with the induction of an efficient immune response could be considered. In conclusion, optimal vaccination strategy needs to balance the levels of passive immunity, the management practices and timing of infection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Italy 1 2%
Unknown 58 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 15%
Student > Master 9 15%
Researcher 8 13%
Other 6 10%
Professor 6 10%
Other 13 22%
Unknown 9 15%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 23 38%
Agricultural and Biological Sciences 10 17%
Medicine and Dentistry 7 12%
Biochemistry, Genetics and Molecular Biology 3 5%
Immunology and Microbiology 2 3%
Other 3 5%
Unknown 12 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2019.
All research outputs
#4,882,741
of 16,414,025 outputs
Outputs from BMC Veterinary Research
#381
of 2,421 outputs
Outputs of similar age
#84,018
of 267,211 outputs
Outputs of similar age from BMC Veterinary Research
#2
of 14 outputs
Altmetric has tracked 16,414,025 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,421 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,211 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.