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Diagnosis of placental malaria in poorly fixed and processed placental tissue

Overview of attention for article published in Malaria Journal, May 2016
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Title
Diagnosis of placental malaria in poorly fixed and processed placental tissue
Published in
Malaria Journal, May 2016
DOI 10.1186/s12936-016-1314-6
Pubmed ID
Authors

Yunhao Liu, Jennifer B. Griffin, Atis Muehlenbachs, Stephen J. Rogerson, Anya J. Bailis, Rajni Sharma, David J. Sullivan, Antoinette K. Tshefu, Sarah H. Landis, Jean-Marie M. Kabongo, Steve M. Taylor, Steven R. Meshnick

Abstract

Placental histopathology has been considered the gold standard for diagnosis of malaria during pregnancy. However, in under-resourced areas placental tissue is often improperly fixed and processed; the resulting formalin pigment is difficult to distinguish from malaria pigment. This study examines two alternative diagnostic methods: polymerase chain reaction (PCR) and a novel immunohistochemistry (IHC)-based method using an antibody against histidine-rich protein 2 (HRP2). Placental histopathology from 151 pregnant women in Kinshasa was assessed by two blinded microscopists and compared with peripheral blood PCR and IHC for HRP2. The Cohen's kappa coefficients were calculated to assess the test agreement. The sensitivity and specificity of individual tests were calculated using PCR or IHC as the reference standard as well as latent class analysis (LCA). PCR and IHC correlated fairly well. The correlation between the two blinded microscopists was poor, as there was widespread formalin pigment. Using LCA, all of the tests had high specificities. The most sensitive test was IHC (67.7 %), with PCR as second-best (56.1 %). PCR and/or IHC are suitable diagnostics when the presence of formalin pigment substantially compromises placental histopathology.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 19%
Student > Master 9 16%
Researcher 6 10%
Student > Ph. D. Student 4 7%
Student > Doctoral Student 3 5%
Other 8 14%
Unknown 17 29%
Readers by discipline Count As %
Medicine and Dentistry 15 26%
Nursing and Health Professions 5 9%
Immunology and Microbiology 4 7%
Agricultural and Biological Sciences 4 7%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 7 12%
Unknown 21 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2019.
All research outputs
#13,469,259
of 22,869,263 outputs
Outputs from Malaria Journal
#3,532
of 5,578 outputs
Outputs of similar age
#150,846
of 304,990 outputs
Outputs of similar age from Malaria Journal
#91
of 153 outputs
Altmetric has tracked 22,869,263 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,578 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,990 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.