Title |
Large-scale proteomic identification of S100 proteins in breast cancer tissues
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Published in |
BMC Cancer, September 2010
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DOI | 10.1186/1471-2407-10-476 |
Pubmed ID | |
Authors |
Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz, Ida Pucci-Minafra |
Abstract |
Attempts to reduce morbidity and mortality in breast cancer is based on efforts to identify novel biomarkers to support prognosis and therapeutic choices. The present study has focussed on S100 proteins as a potentially promising group of markers in cancer development and progression. One reason of interest in this family of proteins is because the majority of the S100 genes are clustered on a region of human chromosome 1q21 that is prone to genomic rearrangements. Moreover, there is increasing evidence that S100 proteins are often up-regulated in many cancers, including breast, and this is frequently associated with tumour progression. |
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Unknown | 8 | 28% |