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Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

Overview of attention for article published in BMC Cancer, February 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

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1 X user
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9 patents

Citations

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29 Dimensions

Readers on

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33 Mendeley
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1 CiteULike
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Title
Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency
Published in
BMC Cancer, February 2011
DOI 10.1186/1471-2407-11-61
Pubmed ID
Authors

Xiaoqin Yuan, Xinjian Lin, Gerald Manorek, Stephen B Howell

Abstract

Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remains a particular challenge. Claudins 3 and 4 are tight junction proteins that are over-expressed in many types of tumors. This study utilized the C-terminal 30 amino acid fragment of C. perfringens enterotoxin (CPE), which binds to claudins 3 and 4, to deliver a toxin in the form of recombinant gelonin (rGel) to the cytoplasm of the human ovarian carcinoma cell line 2008.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 27%
Researcher 6 18%
Professor > Associate Professor 4 12%
Student > Bachelor 2 6%
Professor 2 6%
Other 6 18%
Unknown 4 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 27%
Agricultural and Biological Sciences 7 21%
Chemistry 4 12%
Engineering 3 9%
Immunology and Microbiology 1 3%
Other 3 9%
Unknown 6 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2021.
All research outputs
#4,484,951
of 22,665,794 outputs
Outputs from BMC Cancer
#1,129
of 8,243 outputs
Outputs of similar age
#30,437
of 183,313 outputs
Outputs of similar age from BMC Cancer
#6
of 29 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,243 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,313 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.