Title |
|
---|---|
Published in |
Genome Biology, January 2001
|
DOI | 10.1186/gb-2001-2-1-reviews3002 |
Pubmed ID | |
Authors |
M Mar Albà |
Abstract |
Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and eukaryotic DNA polymerase alpha, and the bacterial polymerase III class make up type C. Structures have been solved for several type A and B polymerases, which share a similar architecture. The structure of type C is not yet known. The catalytic mechanism of all three types involves two metal-ion-binding acidic residues in the active site. Replicative polymerases are constitutively expressed, but their activity is regulated through the cell cycle and in response to different growth conditions. |
Twitter Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 89 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 3% |
Librarian | 1 | 1% |
Unspecified | 1 | 1% |
Student > Ph. D. Student | 1 | 1% |
Student > Master | 1 | 1% |
Other | 0 | 0% |
Unknown | 82 | 92% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 1% |
Unspecified | 1 | 1% |
Social Sciences | 1 | 1% |
Chemistry | 1 | 1% |
Other | 0 | 0% |
Unknown | 83 | 93% |