Title |
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
|
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Published in |
Journal of Neuroinflammation, December 2005
|
DOI | 10.1186/1742-2094-2-29 |
Pubmed ID | |
Authors |
Jared Ehrhart, Demian Obregon, Takashi Mori, Huayan Hou, Nan Sun, Yun Bai, Thomas Klein, Francisco Fernandez, Jun Tan, R Douglas Shytle |
Abstract |
Activated microglial cells have been implicated in a number of neurodegenerative disorders, including Alzheimer's disease (AD), multiple sclerosis (MS), and HIV dementia. It is well known that inflammatory mediators such as nitric oxide (NO), cytokines, and chemokines play an important role in microglial cell-associated neuron cell damage. Our previous studies have shown that CD40 signaling is involved in pathological activation of microglial cells. Many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (CB2). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 223 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 18% |
Researcher | 38 | 17% |
Student > Bachelor | 36 | 16% |
Student > Master | 23 | 10% |
Student > Doctoral Student | 16 | 7% |
Other | 25 | 11% |
Unknown | 48 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 36 | 16% |
Agricultural and Biological Sciences | 32 | 14% |
Medicine and Dentistry | 26 | 11% |
Biochemistry, Genetics and Molecular Biology | 25 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 7% |
Other | 29 | 13% |
Unknown | 62 | 27% |