Title |
Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway
|
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Published in |
Journal of Neuroinflammation, May 2012
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DOI | 10.1186/1742-2094-9-91 |
Pubmed ID | |
Authors |
Vijay Ramesh, Deepti Nair, Shelley X L Zhang, Fahed Hakim, Navita Kaushal, Foaz Kayali, Yang Wang, Richard C Li, Alba Carreras, David Gozal |
Abstract |
Sleepiness and cognitive dysfunction are recognized as prominent consequences of sleep deprivation. Experimentally induced short-term sleep fragmentation, even in the absence of any reductions in total sleep duration, will lead to the emergence of excessive daytime sleepiness and cognitive impairments in humans. Tumor necrosis factor (TNF)-α has important regulatory effects on sleep, and seems to play a role in the occurrence of excessive daytime sleepiness in children who have disrupted sleep as a result of obstructive sleep apnea, a condition associated with prominent sleep fragmentation. The aim of this study was to examine role of the TNF-α pathway after long-term sleep fragmentation in mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
France | 1 | <1% |
Colombia | 1 | <1% |
India | 1 | <1% |
Uruguay | 1 | <1% |
Unknown | 100 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 22% |
Researcher | 23 | 22% |
Student > Master | 9 | 8% |
Other | 8 | 8% |
Student > Doctoral Student | 7 | 7% |
Other | 19 | 18% |
Unknown | 17 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 22% |
Neuroscience | 23 | 22% |
Agricultural and Biological Sciences | 11 | 10% |
Psychology | 9 | 8% |
Biochemistry, Genetics and Molecular Biology | 6 | 6% |
Other | 9 | 8% |
Unknown | 25 | 24% |