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Attention Score in Context
| Title |
Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2locus
|
|---|---|
| Published in |
Retrovirology, September 2009
|
| DOI | 10.1186/1742-4690-6-79 |
| Pubmed ID | |
| Authors |
Koichiro Yamada, Tomonori Tsukahara, Kazuhisa Yoshino, Katsuhiko Kojima, Hideyuki Agawa, Yuki Yamashita, Yuji Amano, Mariko Hatta, Yasunori Matsuzaki, Naoki Kurotori, Keiko Wakui, Yoshimitsu Fukushima, Ryosuke Osada, Tanri Shiozawa, Kazuo Sakashita, Kenichi Koike, Satoru Kumaki, Nobuyuki Tanaka, Toshikazu Takeshita |
| Abstract |
Therapeutic retroviral vector integration near the oncogene LMO2 is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the LMO2 locus. We identified a high incidence region (HIR) of vector integration using PCR techniques in the upstream region close to the LMO2 transcription start site in the TPA-Mat T cell line. The integration frequency of the HIR was one per 4.46 x 10(4) cells. This HIR was also found in Jurkat T cells but was absent from HeLa cells. Furthermore, using human cord blood-derived CD34+ cells we identified a HIR in a similar region as the TPA-Mat T cell line. One of the X-linked severe combined immunodeficiency (X-SCID) patients that developed leukemia after gene therapy had a vector integration site in this HIR. Therefore, the descriptions of the location and the integration frequency of the HIR presented here may help us to better understand vector-induced leukemogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| India | 1 | 10% |
| Unknown | 7 | 70% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 50% |
| Student > Ph. D. Student | 2 | 20% |
| Professor > Associate Professor | 1 | 10% |
| Student > Doctoral Student | 1 | 10% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 60% |
| Medicine and Dentistry | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 1 | 10% |
| Unknown | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2012.
All research outputs
#18,306,425
of 22,665,794 outputs
Outputs from Retrovirology
#953
of 1,102 outputs
Outputs of similar age
#83,392
of 91,322 outputs
Outputs of similar age from Retrovirology
#15
of 17 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,102 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.