the ER stressor thapsigargin (Tg) is an instrumental experimental tool. Additionally, Tg forms the basis for analog prodrugs designed for cell killing in targeted cancer therapy. Tg induces apoptosis via the unfolded protein response (UPR), https://t.co/
Triggering cell death is one way to fight #cancer, and this @BioMedCentral study investigates how this could be done by putting stress on the endoplasmic reticulum, an organelle responsible for protein folding in a cell: https://t.co/DzYG371fb2 https://t.c
https://t.co/isQKSiqhx2 Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica.
Nordic EMBL Partnership collaboration reveals mechanisms of cell death linked to calcium transport. https://t.co/e0tL0u0x6N. Collaborative effort involves researchers at @AarhusUni, @uni_copenhagen, @NCMMnews and @dandrite. Read the publication here https