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Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation

Overview of attention for article published in Clinical and Translational Allergy, May 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)

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Title
Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation
Published in
Clinical and Translational Allergy, May 2016
DOI 10.1186/s13601-016-0108-9
Pubmed ID
Authors

Bodo C. Melnik, Swen Malte John, Pedro Carrera-Bastos, Gerd Schmitz

Abstract

Breastfeeding has protective effects for the development of allergies and atopy. Recent evidence underlines that consumption of unboiled farm milk in early life is a key factor preventing the development of atopic diseases. Farm milk intake has been associated with increased demethylation of FOXP3 and increased numbers of regulatory T cells (Tregs). Thus, the questions arose which components of farm milk control the differentiation and function of Tregs, critical T cell subsets that promote tolerance induction and inhibit the development of allergy and autoimmunity. Based on translational research we identified at least six major signalling pathways that could explain milk's biological role controlling stable FoxP3 expression and Treg differentiation: (1) via maintaining appropriate magnitudes of Akt-mTORC1 signalling, (2) via transfer of milk fat-derived long-chain ω-3 fatty acids, (3) via transfer of milk-derived exosomal microRNAs that apparently decrease FOXP3 promoter methylation, (4) via transfer of exosomal transforming growth factor-β, which induces SMAD2/SMAD3-dependent FoxP3 expression, (5) via milk-derived Bifidobacterium and Lactobacillus species that induce interleukin-10 (IL-10)-mediated differentiation of Tregs, and (6) via milk-derived oligosaccharides that serve as selected nutrients for the growth of bifidobacteria in the intestine of the new born infant. Accumulating evidence underlines that milk is a complex signalling and epigenetic imprinting network that promotes stable FoxP3 expression and long-lasting Treg differentiation, crucial postnatal events preventing atopic and autoimmune diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 105 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 17%
Researcher 18 17%
Student > Master 18 17%
Student > Bachelor 9 8%
Professor 6 6%
Other 18 17%
Unknown 19 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 25%
Medicine and Dentistry 19 18%
Biochemistry, Genetics and Molecular Biology 16 15%
Immunology and Microbiology 7 7%
Nursing and Health Professions 3 3%
Other 10 9%
Unknown 24 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2016.
All research outputs
#6,437,589
of 22,870,727 outputs
Outputs from Clinical and Translational Allergy
#352
of 667 outputs
Outputs of similar age
#95,553
of 311,729 outputs
Outputs of similar age from Clinical and Translational Allergy
#8
of 11 outputs
Altmetric has tracked 22,870,727 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 667 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,729 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.