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Seroepidemiology and molecular diversity of Leishmania donovani complex in Georgia

Overview of attention for article published in Parasites & Vectors, May 2016
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4 tweeters

Citations

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6 Dimensions

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52 Mendeley
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Title
Seroepidemiology and molecular diversity of Leishmania donovani complex in Georgia
Published in
Parasites & Vectors, May 2016
DOI 10.1186/s13071-016-1558-6
Pubmed ID
Authors

Giorgi Babuadze, Jason Farlow, Harry P. de Koning, Eugenia Carrillo, Giorgi Chakhunashvili, Mari Murskvaladze, Merab Kekelidze, Irakli Karseladze, Nora Kokaia, Irine Kalandadze, David Tsereteli, Ivane Markhvashvili, Ketevan Sidamonidze, Gvantsa Chanturia, Ekaterine Adeishvili, Paata Imnadze

Abstract

Leishmaniasis includes multiple clinical syndromes, most notably visceral, cutaneous, and mucosal forms. Visceral leishmaniasis (VL), also known as kala-azar, is a potentially fatal disease endemic to large parts of Africa and Asia, and in South-Eastern Europe (Greece, Turkey, Georgia). Visceral leishmaniasis is a parasitic zoonosis caused by species of the L. donovani complex. In the classical epidemiological model the main reservoir for VL are canines. The study included a cohort of 513 individuals of both genders (190 males and 323 females) from the ages of 1 to 70 years that were screened in ten villages across two districts in Kakheti using the Kalazar Detect™ rK39 rapid diagnostic test. The phylogenetic diversity patterns of local strains, based on the rDNA internal transcribed spacer (ITS) sequences, were assessed for samples obtained from patients with suspected L. donovani infection, from canine reservoirs and from Phlebotomus sand flies obtained from different geographical areas of Georgia and from Azerbaijan. Out of a total of 600 domestic dog blood samples 95 (15.8 %) were positive by rK39 rapid diagnostic tests. For symptomatic domestic dogs, the testing of conjunctival swabs or bone marrow aspirates revealed a higher VL incidence in Kvareli District (Kvareli; 19.4 %, n = 329) compared with that observed for Sagarejo District (Sagarejo; 11.4 %, n = 271). A total of 231 sand flies of both genders were collected during the 2-month period; of the 114 females, 1.75 % were PCR positive for the presence of Leishmania spp. VL infection rates remain high in both canines and humans in Georgia, with disease in several known natural foci. The genetic relationships derived from rDNA internal transcribed spacer (ITS) sequence comparisons identified genetic subgroups, revealing preliminary insights into the genetic structure of L. donovani complex members currently circulating in the South Caucasus and demonstrates the utility of ITS-based genotyping in the resource-limited country of Georgia.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Unknown 51 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 21%
Student > Ph. D. Student 10 19%
Researcher 6 12%
Professor 3 6%
Student > Bachelor 3 6%
Other 8 15%
Unknown 11 21%
Readers by discipline Count As %
Medicine and Dentistry 8 15%
Biochemistry, Genetics and Molecular Biology 8 15%
Veterinary Science and Veterinary Medicine 6 12%
Agricultural and Biological Sciences 6 12%
Nursing and Health Professions 3 6%
Other 7 13%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2016.
All research outputs
#4,086,663
of 7,811,999 outputs
Outputs from Parasites & Vectors
#1,224
of 2,163 outputs
Outputs of similar age
#146,712
of 270,054 outputs
Outputs of similar age from Parasites & Vectors
#107
of 188 outputs
Altmetric has tracked 7,811,999 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,163 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,054 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.