Title |
The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia
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Published in |
BMC Research Notes, March 2012
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DOI | 10.1186/1756-0500-5-146 |
Pubmed ID | |
Authors |
Daniel Martins-de-Souza, Murtada Alsaif, Agnes Ernst, Laura W Harris, Nancy Aerts, Ilse Lenaerts, Pieter J Peeters, Bob Amess, Hassan Rahmoune, Sabine Bahn, Paul C Guest |
Abstract |
Establishing preclinical models is essential for novel drug discovery in schizophrenia. Most existing models are characterized by abnormalities in behavioral readouts, which are informative, but do not necessarily translate to the symptoms of the human disease. Therefore, there is a necessity of characterizing the preclinical models from a molecular point of view. Selective reaction monitoring (SRM) has already shown promise in preclinical and clinical studies for multiplex measurement of diagnostic, prognostic and treatment-related biomarkers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Netherlands | 1 | 2% |
Unknown | 49 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 29% |
Student > Master | 8 | 16% |
Student > Bachelor | 8 | 16% |
Other | 6 | 12% |
Researcher | 3 | 6% |
Other | 7 | 14% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 18 | 35% |
Medicine and Dentistry | 10 | 20% |
Neuroscience | 5 | 10% |
Psychology | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Other | 6 | 12% |
Unknown | 5 | 10% |