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Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

Overview of attention for article published in BMC Biology, July 2011
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Title
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
Published in
BMC Biology, July 2011
DOI 10.1186/1741-7007-9-48
Pubmed ID
Authors

Alexei V Korennykh, Pascal F Egea, Andrei A Korostelev, Janet Finer-Moore, Robert M Stroud, Chao Zhang, Kevan M Shokat, Peter Walter

Abstract

Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell. Ire1 signals, in a transcriptional program, the unfolded protein response (UPR) via the coordinated action of its protein kinase and RNase domains. In this study, we investigated how the binding of cofactors to the kinase domain of Ire1 modulates its RNase activity.

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Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Singapore 1 1%
Unknown 82 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 25%
Researcher 17 20%
Student > Bachelor 9 11%
Professor 7 8%
Professor > Associate Professor 7 8%
Other 21 25%
Unknown 3 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 52%
Biochemistry, Genetics and Molecular Biology 25 29%
Chemistry 8 9%
Medicine and Dentistry 2 2%
Physics and Astronomy 1 1%
Other 2 2%
Unknown 3 4%