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T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

Overview of attention for article published in Arthritis Research & Therapy, May 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 X user
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1 patent
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1 research highlight platform

Citations

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114 Dimensions

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112 Mendeley
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Title
T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles
Published in
Arthritis Research & Therapy, May 2012
DOI 10.1186/ar3848
Pubmed ID
Authors

Soi Cheng Law, Shayna Street, Chien-Hsiung Alan Yu, Christelle Capini, Sakoontalla Ramnoruth, Hendrik J Nel, Eline van Gorp, Claire Hyde, Kim Lau, Helen Pahau, Anthony W Purcell, Ranjeny Thomas

Abstract

Anti-citrullinated peptide antibodies are found in rheumatoid arthritis (RA) patients with HLA-DRβ chains encoding the shared epitope (SE) sequence. Citrullination increases self-antigen immunogenicity, through increased binding affinity to SE-containing HLA-DR molecules. To characterise T-cell autoreactivity towards citrullinated self-epitopes, we profiled responses of SE+ healthy controls and RA patients to citrullinated and unmodified epitopes of four autoantigens.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Sweden 1 <1%
Germany 1 <1%
Unknown 109 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 21%
Student > Ph. D. Student 21 19%
Student > Bachelor 18 16%
Student > Postgraduate 5 4%
Professor 5 4%
Other 17 15%
Unknown 22 20%
Readers by discipline Count As %
Immunology and Microbiology 21 19%
Medicine and Dentistry 20 18%
Agricultural and Biological Sciences 20 18%
Biochemistry, Genetics and Molecular Biology 15 13%
Chemistry 3 3%
Other 7 6%
Unknown 26 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2015.
All research outputs
#7,046,566
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#1,459
of 3,380 outputs
Outputs of similar age
#47,098
of 176,742 outputs
Outputs of similar age from Arthritis Research & Therapy
#15
of 78 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,742 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.