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A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci

Overview of attention for article published in Epigenetics & Chromatin, May 2012
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Mentioned by

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2 tweeters

Citations

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13 Dimensions

Readers on

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65 Mendeley
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2 CiteULike
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Title
A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci
Published in
Epigenetics & Chromatin, May 2012
DOI 10.1186/1756-8935-5-6
Pubmed ID
Authors

James G D Prendergast, Pin Tong, David C Hay, Susan M Farrington, Colin A M Semple

Abstract

Chromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controlling several disease loci. Human genetic variation, DNA methylation, and disease have been intensely studied, uncovering many sites of allele-specific DNA methylation (ASM). However, little is known about the genome-wide occurrence of sites of allele-specific histone modification (ASHM) and their relationship to human disease. The aim of this study was to investigate the extent and characteristics of sites of ASHM in human embryonic stem cells (hESCs).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Norway 1 2%
United Kingdom 1 2%
Korea, Republic of 1 2%
Japan 1 2%
United States 1 2%
Unknown 59 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 34%
Student > Master 11 17%
Student > Ph. D. Student 10 15%
Professor > Associate Professor 4 6%
Student > Bachelor 4 6%
Other 9 14%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 54%
Biochemistry, Genetics and Molecular Biology 11 17%
Medicine and Dentistry 6 9%
Neuroscience 3 5%
Social Sciences 1 2%
Other 3 5%
Unknown 6 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2012.
All research outputs
#7,804,665
of 12,440,173 outputs
Outputs from Epigenetics & Chromatin
#287
of 358 outputs
Outputs of similar age
#66,171
of 118,957 outputs
Outputs of similar age from Epigenetics & Chromatin
#1
of 1 outputs
Altmetric has tracked 12,440,173 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 358 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,957 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them