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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

Overview of attention for article published in Molecular Brain, May 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

blogs
1 blog
twitter
5 X users
patent
1 patent
facebook
2 Facebook pages

Citations

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202 Dimensions

Readers on

mendeley
313 Mendeley
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Title
Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
Published in
Molecular Brain, May 2012
DOI 10.1186/1756-6606-5-17
Pubmed ID
Authors

Tarja A Juopperi, Woon Ryoung Kim, Cheng-Hsuan Chiang, Huimei Yu, Russell L Margolis, Christopher A Ross, Guo-li Ming, Hongjun Song

Abstract

Huntington's Disease (HD) is a devastating neurodegenerative disorder that clinically manifests as motor dysfunction, cognitive impairment and psychiatric symptoms. There is currently no cure for this progressive and fatal disorder. The causative mutation of this hereditary disease is a trinucleotide repeat expansion (CAG) in the Huntingtin gene that results in an expanded polyglutamine tract. Multiple mechanisms have been proposed to explain the preferential striatal and cortical degeneration that occurs with HD, including non-cell-autonomous contribution from astrocytes. Although numerous cell culture and animal models exist, there is a great need for experimental systems that can more accurately replicate the human disease. Human induced pluripotent stem cells (iPSCs) are a remarkable new tool to study neurological disorders because this cell type can be derived from patients as a renewable, genetically tractable source for unlimited cells that are difficult to acquire, such as neurons and astrocytes. The development of experimental systems based on iPSC technology could aid in the identification of molecular lesions and therapeutic treatments.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 313 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
United Kingdom 2 <1%
Australia 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 303 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 82 26%
Researcher 62 20%
Student > Master 37 12%
Student > Bachelor 28 9%
Student > Doctoral Student 13 4%
Other 54 17%
Unknown 37 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 106 34%
Neuroscience 58 19%
Biochemistry, Genetics and Molecular Biology 40 13%
Medicine and Dentistry 33 11%
Engineering 7 2%
Other 25 8%
Unknown 44 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2017.
All research outputs
#2,053,149
of 22,665,794 outputs
Outputs from Molecular Brain
#64
of 1,103 outputs
Outputs of similar age
#13,410
of 163,622 outputs
Outputs of similar age from Molecular Brain
#1
of 8 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,622 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them