Title |
Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
|
---|---|
Published in |
Molecular Brain, May 2012
|
DOI | 10.1186/1756-6606-5-17 |
Pubmed ID | |
Authors |
Tarja A Juopperi, Woon Ryoung Kim, Cheng-Hsuan Chiang, Huimei Yu, Russell L Margolis, Christopher A Ross, Guo-li Ming, Hongjun Song |
Abstract |
Huntington's Disease (HD) is a devastating neurodegenerative disorder that clinically manifests as motor dysfunction, cognitive impairment and psychiatric symptoms. There is currently no cure for this progressive and fatal disorder. The causative mutation of this hereditary disease is a trinucleotide repeat expansion (CAG) in the Huntingtin gene that results in an expanded polyglutamine tract. Multiple mechanisms have been proposed to explain the preferential striatal and cortical degeneration that occurs with HD, including non-cell-autonomous contribution from astrocytes. Although numerous cell culture and animal models exist, there is a great need for experimental systems that can more accurately replicate the human disease. Human induced pluripotent stem cells (iPSCs) are a remarkable new tool to study neurological disorders because this cell type can be derived from patients as a renewable, genetically tractable source for unlimited cells that are difficult to acquire, such as neurons and astrocytes. The development of experimental systems based on iPSC technology could aid in the identification of molecular lesions and therapeutic treatments. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Australia | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
United Kingdom | 2 | <1% |
Australia | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 303 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 82 | 26% |
Researcher | 62 | 20% |
Student > Master | 37 | 12% |
Student > Bachelor | 28 | 9% |
Student > Doctoral Student | 13 | 4% |
Other | 54 | 17% |
Unknown | 37 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 106 | 34% |
Neuroscience | 58 | 19% |
Biochemistry, Genetics and Molecular Biology | 40 | 13% |
Medicine and Dentistry | 33 | 11% |
Engineering | 7 | 2% |
Other | 25 | 8% |
Unknown | 44 | 14% |