Title |
Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study
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Published in |
BMC Medicine, May 2016
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DOI | 10.1186/s12916-016-0617-3 |
Pubmed ID | |
Authors |
Helen A. Fletcher, Ali Filali-Mouhim, Elisa Nemes, Anthony Hawkridge, Alana Keyser, Samuel Njikan, Mark Hatherill, Thomas J. Scriba, Brian Abel, Benjamin M. Kagina, Ashley Veldsman, Nancy Marín Agudelo, Gilla Kaplan, Gregory D. Hussey, Rafick-Pierre Sekaly, Willem A. Hanekom, the BCG study team |
Abstract |
An incomplete understanding of the immunological mechanisms underlying protection against tuberculosis (TB) hampers the development of new vaccines against TB. We aimed to define host correlates of prospective risk of TB disease following bacille Calmette-Guérin (BCG) vaccination. In this study, 5,726 infants vaccinated with BCG at birth were enrolled. Host responses in blood collected at 10 weeks of age were compared between infants who developed pulmonary TB disease during 2 years of follow-up (cases) and those who remained healthy (controls). Comprehensive gene expression and cellular and soluble marker analysis failed to identify a correlate of risk. We showed that distinct host responses after BCG vaccination may be the reason: two major clusters of gene expression, with different myeloid and lymphoid activation and inflammatory patterns, were evident when all infants were examined together. Cases from each cluster demonstrated distinct patterns of gene expression, which were confirmed by cellular assays. Distinct patterns of host responses to Mycobacterium bovis BCG suggest that novel TB vaccines may also elicit distinct patterns of host responses. This diversity should be considered in future TB vaccine development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 50% |
Ireland | 1 | 17% |
United States | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 82 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 23% |
Student > Ph. D. Student | 16 | 19% |
Student > Master | 12 | 14% |
Student > Bachelor | 5 | 6% |
Student > Doctoral Student | 4 | 5% |
Other | 11 | 13% |
Unknown | 16 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 18 | 22% |
Agricultural and Biological Sciences | 13 | 16% |
Medicine and Dentistry | 13 | 16% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Nursing and Health Professions | 4 | 5% |
Other | 7 | 8% |
Unknown | 20 | 24% |