Title |
Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study
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Published in |
BMC Pediatrics, May 2012
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DOI | 10.1186/1471-2431-12-45 |
Pubmed ID | |
Authors |
Timo R de Haan, Yuma A Bijleveld, Johanna H van der Lee, Floris Groenendaal, Marcel PH van den Broek, Carin MA Rademaker, Henrica LM van Straaten, Mirjam M van Weissenbruch, Jeroen R Vermeulen, Peter H Dijk, Jeroen Dudink, Monique Rijken, Arno van Heijst, Koen P Dijkman, Danilo Gavilanes, Anton H van Kaam, Martin Offringa, Ron AA Mathôt |
Abstract |
In the Netherlands, perinatal asphyxia (severe perinatal oxygen shortage) necessitating newborn resuscitation occurs in at least 200 of the 180-185.000 newly born infants per year. International randomized controlled trials have demonstrated an improved neurological outcome with therapeutic hypothermia. During hypothermia neonates receive sedative, analgesic, anti-epileptic and antibiotic drugs. So far little information is available how the pharmacokinetics (PK) and pharmacodynamics (PD) of these drugs are influenced by post resuscitation multi organ failure and the metabolic effects of the cooling treatment itself. As a result, evidence based dosing guidelines are lacking. This multicenter observational cohort study was designed to answer the question how hypothermia influences the distribution, metabolism and elimination of commonly used drugs in neonatal intensive care. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Italy | 1 | <1% |
Portugal | 1 | <1% |
Austria | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 118 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 18% |
Student > Ph. D. Student | 16 | 13% |
Student > Master | 16 | 13% |
Student > Bachelor | 10 | 8% |
Other | 9 | 7% |
Other | 30 | 24% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 57 | 46% |
Nursing and Health Professions | 11 | 9% |
Neuroscience | 5 | 4% |
Psychology | 3 | 2% |
Social Sciences | 3 | 2% |
Other | 13 | 10% |
Unknown | 32 | 26% |