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Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study

Overview of attention for article published in BMC Pediatrics, May 2012
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Title
Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study
Published in
BMC Pediatrics, May 2012
DOI 10.1186/1471-2431-12-45
Pubmed ID
Authors

Timo R de Haan, Yuma A Bijleveld, Johanna H van der Lee, Floris Groenendaal, Marcel PH van den Broek, Carin MA Rademaker, Henrica LM van Straaten, Mirjam M van Weissenbruch, Jeroen R Vermeulen, Peter H Dijk, Jeroen Dudink, Monique Rijken, Arno van Heijst, Koen P Dijkman, Danilo Gavilanes, Anton H van Kaam, Martin Offringa, Ron AA Mathôt

Abstract

In the Netherlands, perinatal asphyxia (severe perinatal oxygen shortage) necessitating newborn resuscitation occurs in at least 200 of the 180-185.000 newly born infants per year. International randomized controlled trials have demonstrated an improved neurological outcome with therapeutic hypothermia. During hypothermia neonates receive sedative, analgesic, anti-epileptic and antibiotic drugs. So far little information is available how the pharmacokinetics (PK) and pharmacodynamics (PD) of these drugs are influenced by post resuscitation multi organ failure and the metabolic effects of the cooling treatment itself. As a result, evidence based dosing guidelines are lacking. This multicenter observational cohort study was designed to answer the question how hypothermia influences the distribution, metabolism and elimination of commonly used drugs in neonatal intensive care.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Italy 1 <1%
Portugal 1 <1%
Austria 1 <1%
Mexico 1 <1%
Unknown 118 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 18%
Student > Ph. D. Student 16 13%
Student > Master 16 13%
Student > Bachelor 10 8%
Other 9 7%
Other 30 24%
Unknown 21 17%
Readers by discipline Count As %
Medicine and Dentistry 57 46%
Nursing and Health Professions 11 9%
Neuroscience 5 4%
Psychology 3 2%
Social Sciences 3 2%
Other 13 10%
Unknown 32 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2015.
All research outputs
#15,695,859
of 23,323,574 outputs
Outputs from BMC Pediatrics
#2,097
of 3,088 outputs
Outputs of similar age
#105,920
of 165,580 outputs
Outputs of similar age from BMC Pediatrics
#25
of 33 outputs
Altmetric has tracked 23,323,574 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,088 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.