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Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months

Overview of attention for article published in BMC Research Notes, May 2012
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Title
Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months
Published in
BMC Research Notes, May 2012
DOI 10.1186/1756-0500-5-245
Pubmed ID
Authors

Rolf Jorde, Johan Svartberg, Ragnar Martin Joakimsen, Dag H Coucheron

Abstract

Recently a large number of short non-coding-RNAs (microRNAs, (miRNA)) have been identified. These miRNAs act as post-transcriptional regulators where they generally have an inhibitory function. miRNAs are present in all human cells, and they are also detected in serum or plasma. The miRNAs have a broad range of actions, and their biogenesis must therefore be under tight control. One putative regulator of miRNA biogenesis or miRNA level could be vitamin D, an ancient hormone with effects on cell growth and differentiation, apoptosis and the immune system. In our study miRNA were reversed transcribed in total RNA isolated from plasma and analyzed by quantitative real-time PCR (qPCR) using the miRCURY LNA Universal RT microRNA PCR system (Exiqon). In 10 pilot subjects 136 miRNAs were detected in one or more plasma samples drawn at baseline and after 12 months of vitamin D supplementation. The twelve miRNAs that showed the greatest change in expression in these pilots were further analyzed by RT-qPCR of RNA from baseline and 12 months plasma samples in 40 subjects given high dose vitamin D(3) (20.000-40.000 IU per week) and 37 subjects given placebo.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 22%
Student > Ph. D. Student 7 15%
Student > Bachelor 6 13%
Student > Master 5 11%
Student > Doctoral Student 3 7%
Other 8 17%
Unknown 7 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 30%
Medicine and Dentistry 13 28%
Biochemistry, Genetics and Molecular Biology 3 7%
Nursing and Health Professions 2 4%
Immunology and Microbiology 2 4%
Other 1 2%
Unknown 11 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2012.
All research outputs
#9,958,541
of 12,440,173 outputs
Outputs from BMC Research Notes
#1,933
of 2,782 outputs
Outputs of similar age
#84,786
of 119,141 outputs
Outputs of similar age from BMC Research Notes
#25
of 38 outputs
Altmetric has tracked 12,440,173 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,782 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.