Title |
Increased hypoxia-inducible factor 1α expression in lung cells of horses with recurrent airway obstruction
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Published in |
BMC Veterinary Research, May 2012
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DOI | 10.1186/1746-6148-8-64 |
Pubmed ID | |
Authors |
Marie Toussaint, Laurence Fievez, Christophe J Desmet, Dimitri Pirottin, Frédéric Farnir, Fabrice Bureau, Pierre Lekeux |
Abstract |
Recurrent airway obstruction (RAO, also known as equine heaves) is an inflammatory condition caused by exposure of susceptible horses to organic dusts in hay. The immunological processes responsible for the development and the persistence of airway inflammation are still largely unknown. Hypoxia-inducible factor (Hif) is mainly known as a major regulator of energy homeostasis and cellular adaptation to hypoxia. More recently however, Hif also emerged as an essential regulator of innate immune responses. Here, we aimed at investigating the potential involvement of Hif1-α in myeloid cells in horse with recurrent airway obstruction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 27% |
Student > Ph. D. Student | 6 | 20% |
Professor | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Student > Master | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 6 | 20% |
Biochemistry, Genetics and Molecular Biology | 5 | 17% |
Immunology and Microbiology | 5 | 17% |
Agricultural and Biological Sciences | 3 | 10% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 7% |
Unknown | 8 | 27% |