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X Demographics
Mendeley readers
| Title |
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors
|
|---|---|
| Published in |
BMC Biology, May 2012
|
| DOI | 10.1186/1741-7007-10-44 |
| Pubmed ID | |
| Authors |
Céline Castanier, Naima Zemirli, Alain Portier, Dominique Garcin, Nicolas Bidère, Aimé Vazquez, Damien Arnoult |
| Abstract |
During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid production of type I interferons (IFN) and of pro-inflammatory cytokines through the transcription factors IRF3/IRF7 and NF-κB, respectively. While MAVS is essential for this signaling and known to operate through the scaffold protein NEMO and the protein kinase TBK1 that phosphorylates IRF3, its mechanism of action and regulation remain unclear. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 114 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 35% |
| Researcher | 22 | 18% |
| Student > Bachelor | 13 | 11% |
| Student > Master | 9 | 7% |
| Student > Doctoral Student | 5 | 4% |
| Other | 11 | 9% |
| Unknown | 19 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 53% |
| Biochemistry, Genetics and Molecular Biology | 20 | 17% |
| Immunology and Microbiology | 10 | 8% |
| Chemistry | 3 | 2% |
| Medicine and Dentistry | 3 | 2% |
| Other | 2 | 2% |
| Unknown | 19 | 16% |