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Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking?

Overview of attention for article published in Journal for Immunotherapy of Cancer, May 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)

Mentioned by

twitter
4 tweeters

Citations

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52 Dimensions

Readers on

mendeley
64 Mendeley
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Title
Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking?
Published in
Journal for Immunotherapy of Cancer, May 2016
DOI 10.1186/s40425-016-0133-1
Pubmed ID
Authors

Sandra Demaria, Silvia C. Formenti

Abstract

The abscopal effect of radiation describes tumor regression in metastases outside of the field upon treatment of one site, and is mediated by radiation-induced anti-tumor T cells. The ability of radiation to generate an in situ tumor vaccine and improve responses to immunotherapy is under intense investigation in the clinic. Preclinical and clinical evidence shows that multiple factors regulate radiation interaction with the immune system within and outside of the irradiated tumor. Poleszczuk and colleagues developed a mathematical model of T cell trafficking between metastases, and in a recent publication propose that the specific metastatic site irradiated determines the ability of T cells to traffic to other metastases and mediate abscopal responses and should dictate clinical decision making [Poleszczuk et al. Cancer Res 76:1009-18, 2016]. Here we critically discuss this model in light of the currently available information about abscopal responses in mice and patients. Caution in relying upon overly simplified models, before validation in real patients, is recommended.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 25%
Student > Ph. D. Student 11 17%
Student > Master 9 14%
Other 7 11%
Professor > Associate Professor 5 8%
Other 12 19%
Unknown 4 6%
Readers by discipline Count As %
Medicine and Dentistry 26 41%
Immunology and Microbiology 7 11%
Agricultural and Biological Sciences 7 11%
Biochemistry, Genetics and Molecular Biology 6 9%
Engineering 2 3%
Other 6 9%
Unknown 10 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2016.
All research outputs
#4,430,543
of 9,738,305 outputs
Outputs from Journal for Immunotherapy of Cancer
#301
of 437 outputs
Outputs of similar age
#107,104
of 277,078 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#6
of 8 outputs
Altmetric has tracked 9,738,305 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 437 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.