Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice

RT @DrLBoominathan: #How does the SARSCOV2 virus increase the levels of TLR4 in COVID-19 patients? TLR4 deficiency ameliorates age-related…

#How does the SARSCOV2 virus increase the levels of TLR4 in COVID-19 patients? TLR4 deficiency ameliorates age-related cognition decline. https://t.co/Zarih6C3Jj @ICMRDELHI @icmr_niv @WHO @BrainPrize @NobelPrize @NIMHANS_BLR @exosome @mheduNIMHANS @NIH @

調べてみるとβ2M自体も前臨床レベルで認知機能を低下させる可能性があることも報告されている TLR4が海馬の神経新生とsynapse機能の調節、TLR4/MyD88/NF-κB経路を通じて、神経炎症とアポトーシスによるβ2M誘発加齢性認知機能低下に寄与 Open Access #B2MG #AD #papers https://t.co/xKHY0hHidH

Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation https://t.co/Zarih6C3Jj https://t.co/zURVwHLAoe @WHO @NobelPrize @ICMRDELHI @ICMR_RMRCBBSR @UNCResearch @NUS @ccmb_csir @iiscbangal