↓ Skip to main content

Association of peripheral BDNF level with cognition, attention and behavior in preschool children

Overview of attention for article published in Child and Adolescent Psychiatry and Mental Health, May 2016
Altmetric Badge

Mentioned by

reddit
1 Redditor

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
99 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Association of peripheral BDNF level with cognition, attention and behavior in preschool children
Published in
Child and Adolescent Psychiatry and Mental Health, May 2016
DOI 10.1186/s13034-016-0097-4
Pubmed ID
Authors

Chan-Woo Yeom, Young-Ja Park, Sam-Wook Choi, Soo-Young Bhang

Abstract

Brain-derived neurotrophic factor (BDNF) has been reported to affect development, cognition, attention and behavior. However, few studies have investigated preschool children with regard to these areas. We evaluated the relationship between cognition, attention and peripheral blood concentration of BDNF in preschool children. Twenty-eight children (mean age: 6.16 ± 0.60 years) were recruited. For all subjects, serum and plasma BDNF levels were assessed; intelligence was assessed using the Korean standardisation of the Wechsler Intelligence Scale for Children (KEDI-WISC); attention was assessed using the computerised continuous performance test (CCPT), the children's color trails test (CCTT), the Stroop color-word test for preschool children, and the attention-deficit/hyperactivity disorder rating scale (K-ARS); and finally emotional and behavioral problems were assessed using the child behavior checklist (K-CBCL). We confirmed the previously reported correlations between the various psychometric properties assessed and serum and plasma levels of BDNF in our sample. Serum BDNF levels were negatively correlated with both KEDI-WISC full scale IQ (FSIQ, r = -0.39, p = 0.04) and verbal IQ (VIQ, r = -0.05, p = 0.01), but not with the performance IQ (PIQ, r = -0.12, p = 0.56). There were no significant relationships between plasma BDNF level and VIQ, PIQ or FSIQ. No correlations were found between either serum or plasma level of BDNF and any of the attentional measures (CCPT, ARS, CCTT or Stroop color word test). The CBCL total behavioral problem and attention problem sections were positively correlated with plasma BDNF level (r = 0.41, p = 0.03), (r = 0.44, p = 0.02), however, no relationship was found between the serum BDNF and any of the composite CBCL measures. Our results suggest that high peripheral BDNF may be negatively correlated with intelligence, behavioral problems and clinical symptoms of neuro-developmental disorders such as intellectual disability in preschool children. A high peripheral BDNF concentration may, if these findings are further replicated, prove to be a useful biomarker for such issues in preschool children.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Unknown 98 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 15%
Researcher 12 12%
Student > Ph. D. Student 12 12%
Student > Doctoral Student 9 9%
Student > Bachelor 8 8%
Other 16 16%
Unknown 27 27%
Readers by discipline Count As %
Medicine and Dentistry 18 18%
Psychology 14 14%
Neuroscience 9 9%
Nursing and Health Professions 5 5%
Agricultural and Biological Sciences 4 4%
Other 18 18%
Unknown 31 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2016.
All research outputs
#12,838,491
of 14,533,317 outputs
Outputs from Child and Adolescent Psychiatry and Mental Health
#429
of 460 outputs
Outputs of similar age
#221,646
of 265,452 outputs
Outputs of similar age from Child and Adolescent Psychiatry and Mental Health
#7
of 8 outputs
Altmetric has tracked 14,533,317 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 460 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,452 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.