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Redox mechanisms in hepatic chronic wound healing and fibrogenesis

Overview of attention for article published in Fibrogenesis & Tissue Repair, October 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters
patent
1 patent
facebook
3 Facebook pages
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
273 Dimensions

Readers on

mendeley
333 Mendeley
citeulike
2 CiteULike
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Title
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
Published in
Fibrogenesis & Tissue Repair, October 2008
DOI 10.1186/1755-1536-1-5
Pubmed ID
Authors

Erica Novo, Maurizio Parola

Abstract

Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have developed evolutionarily conserved mechanisms and strategies to carefully control the generation of ROS and other oxidative stress-related radical or non-radical reactive intermediates (that is, to maintain redox homeostasis), as well as to 'make use' of these molecules under physiological conditions as tools to modulate signal transduction, gene expression and cellular functional responses (that is, redox signalling). However, a derangement in redox homeostasis, resulting in sustained levels of oxidative stress and related mediators, can play a significant role in the pathogenesis of major human diseases characterized by chronic inflammation, chronic activation of wound healing and tissue fibrogenesis. This review has been designed to first offer a critical introduction to current knowledge in the field of redox research in order to introduce readers to the complexity of redox signalling and redox homeostasis. This will include ready-to-use key information and concepts on ROS, free radicals and oxidative stress-related reactive intermediates and reactions, sources of ROS in mammalian cells and tissues, antioxidant defences, redox sensors and, more generally, the major principles of redox signalling and redox-dependent transcriptional regulation of mammalian cells. This information will serve as a basis of knowledge to introduce the role of ROS and other oxidative stress-related intermediates in contributing to essential events, such as the induction of cell death, the perpetuation of chronic inflammatory responses, fibrogenesis and much more, with a major focus on hepatic chronic wound healing and liver fibrogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Sweden 2 <1%
Brazil 2 <1%
India 1 <1%
France 1 <1%
Indonesia 1 <1%
South Africa 1 <1%
Austria 1 <1%
United Kingdom 1 <1%
Other 6 2%
Unknown 313 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 73 22%
Student > Master 57 17%
Researcher 55 17%
Student > Bachelor 32 10%
Student > Doctoral Student 16 5%
Other 66 20%
Unknown 34 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 97 29%
Medicine and Dentistry 69 21%
Biochemistry, Genetics and Molecular Biology 44 13%
Chemistry 27 8%
Pharmacology, Toxicology and Pharmaceutical Science 10 3%
Other 37 11%
Unknown 49 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2020.
All research outputs
#1,584,843
of 19,280,406 outputs
Outputs from Fibrogenesis & Tissue Repair
#2
of 81 outputs
Outputs of similar age
#10,225
of 137,963 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#1
of 1 outputs
Altmetric has tracked 19,280,406 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 81 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 137,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them