Title |
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
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Published in |
Skeletal Muscle, March 2011
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DOI | 10.1186/2044-5040-1-11 |
Pubmed ID | |
Authors |
Christopher S Fry, Micah J Drummond, Erin L Glynn, Jared M Dickinson, David M Gundermann, Kyle L Timmerman, Dillon K Walker, Shaheen Dhanani, Elena Volpi, Blake B Rasmussen |
Abstract |
Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in older adults, but aging is associated with a smaller amount of training-induced hypertrophy. This may be due in part to an inability to stimulate muscle-protein synthesis (MPS) after an acute bout of RE. We hypothesized that older adults would have impaired mammalian target of rapamycin complex (mTORC)1 signaling and MPS response compared with young adults after acute RE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 38% |
Saudi Arabia | 1 | 8% |
Canada | 1 | 8% |
Switzerland | 1 | 8% |
United Kingdom | 1 | 8% |
Australia | 1 | 8% |
Unknown | 3 | 23% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 62% |
Scientists | 3 | 23% |
Practitioners (doctors, other healthcare professionals) | 2 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 1% |
United Kingdom | 3 | 1% |
Japan | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 281 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 57 | 20% |
Student > Master | 49 | 17% |
Researcher | 33 | 11% |
Student > Bachelor | 25 | 9% |
Professor | 13 | 4% |
Other | 50 | 17% |
Unknown | 63 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 54 | 19% |
Agricultural and Biological Sciences | 41 | 14% |
Medicine and Dentistry | 41 | 14% |
Sports and Recreations | 40 | 14% |
Nursing and Health Professions | 17 | 6% |
Other | 22 | 8% |
Unknown | 75 | 26% |