Title |
Anti-apoptotic gene transcription signature of salivary gland neoplasms
|
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Published in |
BMC Cancer, February 2012
|
DOI | 10.1186/1471-2407-12-61 |
Pubmed ID | |
Authors |
Carolina Cavaliéri Gomes, Vanessa Fátima Bernardes, Marina Gonçalves Diniz, Luiz De Marco, Ricardo Santiago Gomez |
Abstract |
Development of accurate therapeutic approaches to salivary gland neoplasms depends on better understanding of their molecular pathogenesis. Tumour growth is regulated by the balance between proliferation and apoptosis. Few studies have investigated apoptosis in salivary tumours relying almost exclusively on immunohistochemistry or TUNEL assay. Furthermore, there is no information regarding the mRNA expression profile of apoptotic genes in salivary tumors. Our objective was to investigate the quantitative expression of BCL-2 (anti-apoptotic), BAX and Caspase3 (pro-apoptotic genes) mRNAs in salivary gland neoplasms and examine the association of these data with tumour size, proliferative activity and p53 staining (parameters associated with a poor prognosis of salivary tumours patients). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 25% |
Student > Bachelor | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Professor | 1 | 5% |
Student > Master | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 45% |
Agricultural and Biological Sciences | 2 | 10% |
Neuroscience | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Unknown | 7 | 35% |