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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Overview of attention for article published in Journal of Inflammation, August 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#13 of 425)
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
1 X user
patent
3 patents
facebook
1 Facebook page

Citations

dimensions_citation
397 Dimensions

Readers on

mendeley
217 Mendeley
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Title
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
Published in
Journal of Inflammation, August 2010
DOI 10.1186/1476-9255-7-41
Pubmed ID
Authors

Debra M Meyer, Michael I Jesson, Xiong Li, Mollisa M Elrick, Christie L Funckes-Shippy, James D Warner, Cindy J Gross, Martin E Dowty, Shashi K Ramaiah, Jeffrey L Hirsch, Matthew J Saabye, Jennifer L Barks, Nandini Kishore, Dale L Morris

Abstract

The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. In RA trials, dose-dependent decreases in neutrophil counts (PBNC) were observed with CP-690,550 treatment. These studies were undertaken to better understand the relationship between JAK selectivity and PBNC decreases observed with CP-690,550 treatment.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Brazil 1 <1%
India 1 <1%
Argentina 1 <1%
Spain 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 210 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 46 21%
Student > Master 27 12%
Student > Ph. D. Student 26 12%
Other 22 10%
Student > Bachelor 20 9%
Other 31 14%
Unknown 45 21%
Readers by discipline Count As %
Medicine and Dentistry 45 21%
Agricultural and Biological Sciences 40 18%
Biochemistry, Genetics and Molecular Biology 25 12%
Chemistry 16 7%
Pharmacology, Toxicology and Pharmaceutical Science 14 6%
Other 20 9%
Unknown 57 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2021.
All research outputs
#1,971,179
of 25,373,627 outputs
Outputs from Journal of Inflammation
#13
of 425 outputs
Outputs of similar age
#6,860
of 104,279 outputs
Outputs of similar age from Journal of Inflammation
#1
of 7 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,279 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them