Title |
Recent advances and novel agents for gastrointestinal stromal tumor (GIST)
|
---|---|
Published in |
Journal of Hematology & Oncology, May 2012
|
DOI | 10.1186/1756-8722-5-21 |
Pubmed ID | |
Authors |
Gurpreet Lamba, Samir Ambrale, Byung Lee, Ridhi Gupta, Shamudheen M Rafiyath, Delong Liu |
Abstract |
The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic "driver" pathways, leading to dramatically improved clinical outcomes. A series of investigations and trials are underway to develop novel and effective ways to treat patients with GIST. In this review, we discuss the highlights of recent advances and novel agents for GIST therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 1 | 3% |
Honduras | 1 | 3% |
Luxembourg | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 28 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 22% |
Student > Bachelor | 6 | 19% |
Student > Doctoral Student | 4 | 13% |
Other | 4 | 13% |
Researcher | 4 | 13% |
Other | 6 | 19% |
Unknown | 1 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 59% |
Agricultural and Biological Sciences | 7 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Physics and Astronomy | 1 | 3% |
Other | 1 | 3% |
Unknown | 1 | 3% |