Title |
Probing the Xenopus laevis inner ear transcriptome for biological function
|
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Published in |
BMC Genomics, June 2012
|
DOI | 10.1186/1471-2164-13-225 |
Pubmed ID | |
Authors |
TuShun R Powers, Selene M Virk, Casilda Trujillo-Provencio, Elba E Serrano |
Abstract |
The senses of hearing and balance depend upon mechanoreception, a process that originates in the inner ear and shares features across species. Amphibians have been widely used for physiological studies of mechanotransduction by sensory hair cells. In contrast, much less is known of the genetic basis of auditory and vestibular function in this class of animals. Among amphibians, the genus Xenopus is a well-characterized genetic and developmental model that offers unique opportunities for inner ear research because of the amphibian capacity for tissue and organ regeneration. For these reasons, we implemented a functional genomics approach as a means to undertake a large-scale analysis of the Xenopus laevis inner ear transcriptome through microarray analysis. |
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