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Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy

Overview of attention for article published in BMC Neuroscience, June 2012
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Title
Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
Published in
BMC Neuroscience, June 2012
DOI 10.1186/1471-2202-13-57
Pubmed ID
Authors

Pavel Haninec, Radek Kaiser, Vladimír Bobek, Petr Dubový

Abstract

Vascular endothelial growth factor (VEGF) is not only a potent angiogenic factor but it also promotes axonal outgrowth and proliferation of Schwann cells. The aim of the present study was to quantitatively assess reinnervation of musculocutaneous nerve (MCN) stumps using motor and primary sensory neurons after plasmid phVEGF transfection and end-to-end (ETE) or end-to-side (ETS) neurorrhaphy. The distal stump of rat transected MCN, was transfected with plasmid phVEGF, plasmid alone or treated with vehiculum and reinnervated following ETE or ETS neurorrhaphy for 2 months. The number of motor and dorsal root ganglia neurons reinnervating the MCN stump was estimated following their retrograde labeling with Fluoro-Ruby and Fluoro-Emerald. Reinnervation of the MCN stumps was assessed based on density, diameter and myelin sheath thickness of regenerated axons, grooming test and the wet weight index of the biceps brachii muscles.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 45%
Student > Postgraduate 2 10%
Student > Doctoral Student 1 5%
Student > Bachelor 1 5%
Lecturer 1 5%
Other 4 20%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 8 40%
Agricultural and Biological Sciences 3 15%
Neuroscience 2 10%
Philosophy 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Other 2 10%
Unknown 3 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2012.
All research outputs
#20,159,700
of 22,668,244 outputs
Outputs from BMC Neuroscience
#1,051
of 1,240 outputs
Outputs of similar age
#150,874
of 166,900 outputs
Outputs of similar age from BMC Neuroscience
#32
of 34 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.