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The ongoing dissection of the genetic architecture of autistic spectrum disorder

Overview of attention for article published in Molecular Autism, June 2012
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1 tweeter

Citations

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16 Dimensions

Readers on

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38 Mendeley
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3 CiteULike
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Title
The ongoing dissection of the genetic architecture of autistic spectrum disorder
Published in
Molecular Autism, June 2012
DOI 10.1186/2040-2392-2-12
Pubmed ID
Authors

Rob F Gillis, Guy A Rouleau

Abstract

The development of robust, non-hypothesis based case/control studies has led to a large push forward towards identifying common genetic variants that contribute to complex traits. However, despite many attempts, the search for common disease-predisposing variants in childhood developmental disorders has largely failed. Recently, a role for rare causal variants and de novo mutations is emerging in the genetic architecture of some of these disorders, particularly those that incur a large degree of selection against the phenotype. In this paper, we examine these data and use classic genetic epidemiological approaches to gain insights into the genetic architecture of ASD. Future studies using next generation sequencing should elucidate the precise role de novo mutations play in disorders traditionally thought to have resulted from polygenic or common disease, common variants inheritance.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Korea, Republic of 1 3%
Germany 1 3%
Israel 1 3%
Italy 1 3%
Unknown 32 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Other 5 13%
Student > Ph. D. Student 5 13%
Professor 4 11%
Student > Bachelor 3 8%
Other 9 24%
Unknown 4 11%
Readers by discipline Count As %
Psychology 9 24%
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 8 21%
Arts and Humanities 3 8%
Social Sciences 2 5%
Other 4 11%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2012.
All research outputs
#3,186,558
of 4,504,824 outputs
Outputs from Molecular Autism
#192
of 198 outputs
Outputs of similar age
#50,183
of 76,367 outputs
Outputs of similar age from Molecular Autism
#5
of 5 outputs
Altmetric has tracked 4,504,824 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 198 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,367 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one.